Apoptosis in Pathological and Physiological context

Apoptosis is a regulated cellular suicide mechanism characterized by nuclear condensation, cell shrinkage, membrane blebbing, and DNA fragmentation.

Programmed cell death, or apoptosis, is a genetically regulated process where cells undergo self-destruction in response to specific signals. These signals can ...

There are two major pathways leading to apoptosis in the mammalian system: an extrinsic pathway initiated by death receptors and an intrinsic ...

Apoptosis can be initiated through one of two pathways. In the intrinsic pathway the cell kills itself because it senses cell stress, while in the extrinsic ... Inhibitor of apoptosis · Apoptosis-inducing factor · History of apoptosis resea

The intrinsic and extrinsic pathways of apoptosis are both naturally occurring processes by which a cell is directed to programmed cell death. Intrinsic pathway of apoptosis · Extrinsic pathway of apoptosis

There are 2 main pathways to apoptotic cell death. One involves the interaction of a death receptor, such as the TNF receptor-1 or the Fas receptor with its ...

The first involves ligation of death receptors by their ligands, resulting in the recruitment of adaptor proteins and procaspase molecules.

The two main pathways of apoptosis are extrinsic and intrinsic as well as a perforin/granzyme pathway . Each requires specific triggering signals to begin an energy-dependent cascade of molecular events. Each pathway activates its own initiator caspa

Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine ...

The mechanism of apoptosis mainly consist of two core pathways involved in inducing apoptosis; extrinsic pathway and intrinsic pathway. Extrinsic pathway refers ...